There is no evidence that women don't vote Republican.
I'm not sure "alienation" has much to do with it. Blacks and hispanics predominantly vote democrat regardless of who the candidates are. You might as well say that past democrat candidates alienated WASPs and Jews.
There was a report on Radio 4 yesterday. Cuban Americans - traditionally Republican voters have changed sides. One was quoted as saying - "why shouldn't I vote Democrat? They've done more for me than the Republicans ever have."
Your point about WASPS and Jews is relevant of course, but more to the point is the fact that Spannish speaking Americans are becoming a very sizeable minority in the US, and so far the Republicans seem to have gone out of their way to upset them. - same goes for women for that matter. The quotes on rape and their attitude to abortion won't have helped their case.
Labour lost in 1979 & 83 with the left saying we lost because we weren't left wing enough. The Tories lost in 1997, 2001 & 2005 with the right saying wwe weren't right wing enough. Cameron learned the lesson. Unfortunately once he got into Downing Street he promptly forgot it.